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Set calories based on body weight, activity, and rate of loss

Studies show that patients who titrate slowly over 8 to 12 weeks experience significantly milder gastrointestinal symptoms compared to those who rapidly increase doses

Therefore, more human studies are needed to confirm these effects

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As with all prescription medicines, this is a breach of the Human Medicines Regulations 2012 and is a matter for enforcement by the MHRA (Medicines and Healthcare products Regulatory Agency)